October 5, or 10/5, is the date of a shooting at University of Arizona?
University of Arizona = 105
Arizona = 105

Notice the killer was 46 years old.
Sacrifice = 46
Execution = 46

Keep in mind it was a Wednesday.
Wednesday = 37 / 44
Shooting = 37 / 44
Execution = 44

https://www.cnn.com/2022/10/05/us/arizona-professor-fatally-shot/index.html

John W. Harshbarger Building = 253 (22nd triangular number)
Shooting in ’22
Shooting at 2 PM